Hyaluronic acid–lipid binding

Relation Between Sperm Binding Ability to Hyaluronic Acid With Protamine Deficiency and DNAFragmentation

Purpose: The best sperm selection by its binding ability to hyaluronic acid for ICSI and assessment of correlation between sperm binding ability to hyaluronic acid with sperm parameters, protamine deficiency and DNA fragmentation. Materials and Methods: Semen samples collected from 55 infertile couples referring to ?? Fertility and Infertility center were collected during this study. Semen ana...

CD44 Binding to Hyaluronic Acid Is Redox Regulated by a Labile Disulfide Bond in the Hyaluronic Acid Binding Site

CD44 is the primary leukocyte cell surface receptor for hyaluronic acid (HA), a component of the extracellular matrix. Enzymatic post translational cleavage of labile disulfide bonds is a mechanism by which proteins are structurally regulated by imparting an allosteric change and altering activity. We have identified one such disulfide bond in CD44 formed by Cys77 and Cys97 that stabilises the ...

Sperm concentration, hyaluronic acid binding capacity, aneuploidy and persistent histones

Bronchial tissue kallikrein activity is regulated by hyaluronic acid binding.

Tissue kallikrein (TK) is secreted by serous cells of tracheobronchial submucosal glands and plays a role in allergic airway responses. To better understand the regulation of TK, we used primary cultures of submucosal gland cells that release TK upon stimulation. Media from cultures stimulated with chymase (10(-7) M) showed increased TK activity (0.50 +/- 0.22 mU/ml mean +/- standard error) in ...

Mechanisms regulating the binding activity of CD44 to hyaluronic acid.

CD44 is a cell surface glycoprotein present on many cell types. Many CD44 isoforms have been identified. All CD44 isoforms utilize identical transmembrane and cytoplasmic domains. The hematopoietic form of CD44 (CD44H) is the major CD44 protein present on normal human lymphocytes and monocytes. One of the ligands for CD44 is hyaluronic acid (HA), a polymer consisting of repeat units of disaccha...